BiologyNEB 2076 (old course)

What is the role of hormones in the human body? Explain the functions of insulin and adrenaline.

5

Answer

Growth Hormone (GH)Thyroid-Stimulating Hormone (TSH)Pituitary GlandThyroxine (T₄)Triiodothyronine (T₃)Thyroid GlandInsulinGlucagonPancreasAdrenaline (Epinephrine)NoradrenalineAdrenal GlandEndocrine GlandsHormones in the Human Body

Hormones are chemical messengers produced by endocrine glands in the human body. They regulate various physiological processes, including growth, metabolism, reproduction, and response to stress. Hormones are secreted directly into the bloodstream and travel to target organs or tissues, where they bind to specific receptors to elicit a response.

Role of Hormones in the Human Body

  1. Regulation of Metabolism: Hormones like insulin and glucagon regulate blood sugar levels.
  2. Growth and Development: Growth hormone (GH) promotes growth and development.
  3. Reproduction: Hormones like estrogen and testosterone regulate reproductive functions.
  4. Stress Response: Adrenaline and cortisol help the body respond to stress and emergencies.
  5. Homeostasis: Hormones maintain balance in the body, such as blood pressure and fluid balance.
Insulin: Lowers blood glucoseGlucagon: Raises blood glucoseMetabolic RegulationAdrenaline: Fight-or-flightCortisol: Long-term stressStress ResponseGrowth Hormone: Bone/muscle growthThyroxine: Metabolic rateGrowth & DevelopmentHormone Functions
Classification of major hormone functions by system

Functions of Insulin

Insulin is a peptide hormone secreted by the beta cells of the islets of Langerhans in the pancreas. Its primary role is to regulate blood glucose levels by facilitating the uptake of glucose into cells.

GlucoseGlucose
Structure of Glucose
  1. Glucose Uptake: Insulin binds to receptors on muscle, fat, and liver cells, promoting the uptake of glucose from the bloodstream into these cells.
  2. Glycogenesis: It stimulates the conversion of glucose into glycogen (glycogenesis) in the liver and muscle cells for storage.
  3. Inhibition of Gluconeogenesis: Insulin inhibits the production of glucose from non-carbohydrate sources (e.g., proteins and fats) in the liver.
  4. Lipogenesis: It promotes the conversion of excess glucose into fatty acids and triglycerides for storage in adipose tissue.
  5. Protein Synthesis: Insulin stimulates the uptake of amino acids into cells, promoting protein synthesis.

Functions of Adrenaline

Adrenaline (also known as epinephrine) is a hormone and neurotransmitter secreted by the adrenal medulla in response to stress or danger. It prepares the body for a "fight-or-flight" response.

0sAdrenaline release(stress detected)5sGlycogenolysisbegins (liver/muscles)10sBlood glucosepeaks, muscles primed30sLipolysisactivated (energy rese1m+Effects subside(return to homeostasis
Adrenaline's rapid physiological timeline during stress
  1. Increased Heart Rate and Blood Pressure: Adrenaline binds to receptors in the heart, increasing heart rate and force of contraction, which raises blood pressure.
  2. Dilation of Airways: It causes the dilation of bronchioles in the lungs, improving oxygen intake.
  3. Glycogenolysis: Adrenaline stimulates the breakdown of glycogen into glucose (glycogenolysis) in the liver and muscles, increasing blood glucose levels.
  4. Lipolysis: It promotes the breakdown of fats (lipolysis) into fatty acids and glycerol, providing energy.
  5. Increased Blood Flow to Muscles: Adrenaline redirects blood flow away from non-essential organs (e.g., digestive system) to muscles, preparing the body for physical activity.
  6. Pupil Dilation: It causes dilation of the pupils, enhancing vision.
GlycerolGlycerol
Structure of Glycerol

In summary, hormones like insulin and adrenaline play critical roles in maintaining homeostasis, responding to stress, and regulating metabolic processes in the human body.

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