PadhaiBy Astra Cloud
Search notes and questions
Ask a doubtProgramsNoticesGPA calculatorMy studyClassroom

Tribhuvan University

BSc CSITBachelor of Science in Computer Science and Information TechnologyBCABachelor of Computer ApplicationBITBachelor of Information TechnologyBIMBachelor of Information ManagementBBABachelor of Business AdministrationBBSBachelor of Business StudiesBBMBachelor of Business ManagementBITMBachelor of Information Technology Management

Pokhara University

BE Computer (PU)Bachelor of Engineering in Computer EngineeringBBA (PU)Bachelor of Business Administration (Pokhara University)

National Examinations Board (+2)

Class 10Class 10 (SEE)+2 Science+2 Science (Class 11 and 12)+2 Management+2 Management (Class 11 and 12)+2 Humanities+2 Humanities (Class 11 and 12)
All universities and programs

Bio Biology

BiologyNEB 2075 (old course)

What is the function of the enzyme 'ligase'?

1

Answer

· Based on the official syllabus and past papers
Updated

Ligase is a crucial enzyme involved in the replication and repair of DNA. Its primary function is to catalyze the formation of phosphodiester bonds between adjacent nucleotides, thereby joining Okazaki fragments during lagging strand synthesis in DNA replication. Specifically:

  • Joins DNA strands: Ligase seals the gaps between Okazaki fragments by covalently linking the 3′-OH end of one DNA fragment to the 5′-phosphate end of another.
  • DNA repair: It plays a role in repairing single-strand breaks in DNA, ensuring genetic stability.
  • Recombination: Ligase facilitates the joining of DNA molecules during homologous recombination and non-homologous end joining (NHEJ).

Ligases require energy, typically provided by ATP or NAD+, to form the phosphodiester bond. This enzyme is essential for maintaining the integrity of the genetic material in cells.

Discussion

Loading…

More Biology questions

Which of the following term describes pollen tube entry into the embryo sac of ovule through micropyle during fertilization? a) Mesogamy b) Chalazogamy c)…NEB 2082 (MCQs)1Which of the following structures in a plant is primarily responsible for regulating transpiration? a) Xylem b) Stomata c) Root hairs d) PhloemNEB 2082 (MCQs)1Which of the following genetic disorders is caused by a point mutation? a) Down's Syndrome b) Turner's Syndrome c) Sickle Cell Anaemia d) Klinetelter's syndromeNEB 2082 (MCQs)1A botanist observes scattered vascular bundles throughout the ground tissue in a plant stem. What is the most appropriate conclusion? a) The plant is monocot.…NEB 2082 (MCQs)1If a plant is placed in a sealed bell jar with limited oxygen, how will its energy production be affected over time? a) ATP production will increase due to…NEB 2082 (MCQs)1Which of the following cell produces histamin and heparin ? a) Plasma cells b) WBC c) Macrophage cells d) Mast cellsNEB 2082 (MCQs)1

All Biology old questions